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March 15, 2024

Bridging Generations in Academic Medicine with Dr. Robert Winn

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Clinician Researcher

Dr. Robert A. Winn is Director of Virginia Commonwealth University (VCU) Massey Comprehensive Cancer Center. Not only does he lead a National Cancer Institute-designated Cancer Center but he also provides advanced cancer care, conducts groundbreaking research to discover new therapies for cancer, offers high-quality education and training, and engages with the community to make advancements in cancer treatment and prevention equally available to all.

In this episode, Dr. Robert discusses the challenges and opportunities in academic medicine, particularly for underrepresented minorities. Dr. Winn shares insights from his own journey and highlights the importance of intergenerational collaboration and mentorship.

Key Points Discussed:

  1. Dr. Winn's journey from humble beginnings to becoming a leader in academic medicine and research.
  2. The importance of recognizing opportunities and being open to new paths, even when they may not align with one's initial plans.
  3. Addressing barriers faced by underrepresented minorities in academic medicine, including the erosion of diversity-focused initiatives.
  4. The need for a shift in mindset to prioritize diversity and inclusion in academic and research settings.
  5. Strategies for creating opportunities and supporting future generations of researchers, including mentorship and intentional networking.

Links and Resources Mentioned:

  1. The Robert A. Winn Diversity In Clinical Trials Award Program
  2. Virginia Commonwealth University Massey Comprehensive Cancer Center
  3. Winn Lab

Call to Action:

Listeners are encouraged to engage in intergenerational conversations and mentorship opportunities within their professional communities. Consider how you can contribute to creating a more inclusive and supportive environment for aspiring researchers and clinicians.

Sponsor/Advertising/Monetization Information:

This episode is sponsored by Coag Coach LLC, a leading provider of coaching resources for clinicians transitioning to become research leaders. Coag Coach LLC is committed to supporting clinicians in their scholarship.

Transcript

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Welcome to the Clinician Researcher podcast, where academic clinicians learn the skills

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to build their own research program, whether or not they have a mentor.

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As clinicians, we spend a decade or more as trainees learning to take care of patients.

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When we finally start our careers, we want to build research programs, but then we find

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that our years of clinical training did not adequately prepare us to lead our research

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program.

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Through no fault of our own, we struggle to find mentors, and when we can't, we quit.

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However, clinicians hold the keys to the greatest research breakthroughs.

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For this reason, the Clinician Researcher podcast exists to give academic clinicians

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the tools to build their own research program, whether or not they have a mentor.

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Now introducing your host, Tracey Onwemona.

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Welcome to the Clinician Researcher podcast.

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I'm your host, Toyosi Onwuemene, and it is such a pleasure to have you on the show.

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Today, I'm especially excited because we have a very special guest, Dr. Robert Winn, and

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he's got so many, so many wonderful things to share, so many deep insights.

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I can't wait for him to share them with you.

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I just want to say, Dr. Winn, welcome to the show.

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Yo, you know what?

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Thank you for having me and appreciate it.

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Oh, it's our pleasure.

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So, Dr. Nguyen, there's so much I could say about you, but I'd love for you to introduce

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yourself, but not just you as the researcher, as the very successful scientist and leader,

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but introduce yourself even from your early beginnings in academic medicine and the secret

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sauce that brought you to this spot where you are today.

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So it's a little bit like, you know, we used to say, you know, I didn't look for thug life,

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thug life found me.

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Well, I ain't looked for medicine.

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It literally found me.

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And what I mean by that is that I'm the example of when people see things in you before you

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even recognize them within yourself.

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And so, you know, I always sort of say to people, they look at me now and they say,

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oh my God, you must have been always, you know, focused and, you know, knew you were

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going to do this.

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And they say, I did not.

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But what I was, was curious enough to understand what an opportunity not to say no.

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And so the story goes that, you know, as I was growing up, I really wasn't thinking about

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becoming a doctor, let alone doing research.

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I mean, I literally was focused on trying to, you know, make some cash and, you know,

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I was thinking about working at GM and, you know, being the youngest formed over at GM

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and luckily that did not work out.

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You know, there were other plans and those other plans were that, you know, I'd wind

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up going to, you know, University of Notre Dame.

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And then I'd run into amazing people who actually, again, got me on a different path because

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I was maybe suspect that they saw something in me, but not actually resistant.

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It's a common theme for me in the context of, you know, wanting to do research, basic

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science.

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This was not something that inherently I grew up with or even was exposed to.

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But I think when I got my first taste of it and having, you know, people around campus

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at that time, University of Michigan, Francis Collins was there, there was a significant

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influence on sort of saying, huh, it's interesting that I could actually help out my people and

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do research.

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And by the way, instead of just helping out the patient in front of me, if I came up with

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something, right, I could really help communities times a hundred or a thousand.

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And so that really kind of got me into the, you know, the mindset that I could become

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a researcher.

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And I'm so glad I did.

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Not because it was just purpose of just generating paper, because it gave me not only a way of

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thinking, but a lifestyle, a lifestyle of not only being curious, but a lifestyle of

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being analytical in that kind of sense of being able to be critically minded.

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And when I actually think about certain things, which is extended, interesting, all the way

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into my work, into this sort of community to bench model where we really put community

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first, the scientific principle and the scientific approaches are still really, really relevant

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as I run a cancer center or when I'm out doing community based participatory activities.

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So it's interesting that in my life, it is not so much that I found it as if the steps

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were ordered so that it, in this case, science would find me.

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And so, I mean, as usually the best way to put it, you know, I mean, I, you know, I am

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the product of what happens when you have federal programs from like Head Start at a

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teenage mom to, you know, the minority supplement awards that came with NIH to all of those

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things that when you invest in us, the ROI can be great.

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And so again, you know, that's my story and I'm straight up sticking to it.

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Thank you, Dr. Nguyen.

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That was super awesome.

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Thank you.

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Thank you for sharing.

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Because what I hear in that is the legacy piece.

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Like I can contribute to something greater than myself.

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I think many young people and especially underrepresented faculty in the academic medicine want to have

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that same kind of impact, but they experience barriers.

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And I, you know, I think every generation feels like them barriers are more significant

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than the generations that came before them.

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But there is a sense that there is less incentive and less investment in clinicians today in

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becoming researchers.

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Can you speak to that?

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What's different today compared to when you came up in research?

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I think it's a mindset.

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Actually, I started thinking about the money.

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And if you look at the money, right, the gross amount, some money that are being spent right

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now versus what was being spent, I'm not quite sure that the money's not there.

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But what I'm sure is that the mindset and the, and really the focus, right, there was

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once upon a time where we really focused on understanding that there were lower numbers

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of minorities that were part of our medical school and lower numbers of minorities that

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were part of the science field.

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And then there was a societal sort of center, we should do something about that.

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What's eroded isn't the money.

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What's eroded is that ethos of making sure that we included diversity and that it was

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good for all of us.

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You know, the funny part is I used to talk about, you know, generation, you know, one

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of my ex, whatever the hell, you know, but I'm definitely not a millennial.

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I know that.

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So it was either ex or wherever in that zone, that early ex, whatever that was.

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And we, you know, we always dogged out, you know, the millennials and everything that

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came after.

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I don't even know where you're at.

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X, Y, Z, A, I don't know.

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But whatever is after us, we have done, I think all of us are dissatisfied by the following

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narrative.

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You guys are softer.

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Here's the reality that I was just talking with Dr. Vivian Penn, who's also a giant in

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our field, and without folks like Vivian Penn, I don't have a foundation to then stand on

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to take things to the next level.

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She and I were talking and she said something that was really just made a light bulb.

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She said, now listen, you know, the difference is that our generation, meaning the baby boomers

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and the exes, we didn't know what better looked like.

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It wasn't there.

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We were all struggling to quote get there.

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But generations that came after us actually had a taste of what good was.

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And in front of your eyes, you're seeing it eroded.

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Now when we talk about that, we don't really talk about these generational differences about

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what makes it different when I don't expect that anybody's going to give me anything.

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When I expect that there's going to be obstacles, because I assume that no one, even in getting

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as a 10 year old chocolate from a white store that when I went into a neighborhood and being

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able to be like shook, you know, shaking down and like, yo, why you in here buying a snicker

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bar?

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I'm like, because my daddy gave me a quarter.

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You know what I'm saying?

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That was an expectation that there was going to be obstacles and that there wasn't anybody

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that was going to set up something for me.

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I was like, what?

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You know, people would say, well, don't you expect that they're going to... No, my expectation

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was that there was going to definitely be like, that's not you, you don't belong here.

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That was, I mean, it's straight up.

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I can't even lie about it.

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So I had to change my mental and say, but what if I grew up in generations where the

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expectation was that things weren't supposed to be the same and that we, as a result of

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the previous generation, had a more of a taste of that, right?

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What then happens is if in my lifetime, I'm now seeing things roll back.

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That mental allows for a sense of saying that you're seeing loss as opposed to understanding

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that we already were in the negative column and people were going to keep you in the negative

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column and that was just normalized.

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What actually happens in the generations that followed when that wasn't the mindset that

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not having was normalized and having was to say, yeah, we're supposed to?

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So I'm actually sort of saying to you in a very roundabout way that I think when we come

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to obstacles, we have to actually have grace for one another in our cultures and our generational

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differences in a sense of younger people recognizing that people from the ex generation, particularly

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early ex, I can't speak for them later exes.

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The later exes, I can't speak for them.

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I'm talking about the ones right in that baby boom to the early ex.

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I can tell you for real, for real that that generation was like me sort of saying that

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we were being the last generation of forced busing where we were being integrated and

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where we actually were in communities where people didn't want us.

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It was an assumption that people didn't want you.

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It was an assumption that things weren't going to be fair and it was an assumption that there

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was always going to be obstacles.

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So once that's your normal, you're like, yeah, all right, but what would it be like if I

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didn't have that mental where I assumed that there was going to be an obstacle and all

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of a sudden in my mind and in my lifetime, we were seeing those things eroded.

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That is a different sort of mentality and that is something that I think when we talk

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about intergenerational, I hope we in the future are able to start those discussions

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so that the younger generations can have a little bit more grace for the older and that

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our older sort of generations can have a little bit more grace in understanding what's going

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on with the framework and the mental of the millennials and all.

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So I think that that's an important thing that in a black community in particular that

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we are not doing that I hope to have future conversations on what that looks like because

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I think that there goes the rubs because when I think of obstacles, I'm like, yeah, of course

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there's obstacles.

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I mean, we were like, well, what do you think about the obstacles?

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I mean, I don't know where it was.

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So, right?

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I love it.

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I appreciate you talking about that.

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I want to, you know, it's interesting.

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So I'm going to go back 10 years when I first started as an early career faculty and there

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were these obstacles that I wasn't expecting.

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And so when you're speaking, it really speaks to me because I'm like, I was not expecting

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those obstacles.

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And you know why?

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Because throughout undergrad, I was supported all the way.

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And then in medical school, I was mostly supported.

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In fact, I was in residency and even in fellowship.

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And then I got to the faculty position.

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And that was where it became clear that there are a lot more obstacles than I had ever experienced.

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And when I talk to someone-

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So that meant that the early work that we put in was working.

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That's a great point.

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That's a great point.

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To lead a medical student and to get the residencies and the fellowship supported because my generation,

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that was not an easy, like, support of what?

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They would be like, man, we hope you go.

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We hope you fail.

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Right?

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It was like, and they were pretty straight up with it.

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You don't belong here.

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And I was like, you're right, but we're going to finish anyway.

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So you are right.

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But what happened was, to your point though, that because of work, we made progress.

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Then what happens is that we need to actually make more progress.

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But in the current age and what you're getting at is that some of the progress being made,

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when you see that roll back, that has to actually hurt in a different way.

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Okay.

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So tell me now, how do we solve this problem?

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Because you're tackling this problem at many different levels.

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And I'm connected with you because I'm a member of the Wynn Career Development Award.

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You can say that again.

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I mean, open it up.

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You don't know me.

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You don't know me.

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I'm a weirdo.

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So I see you just working hard to remove these obstacles, at least give people tools to

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scale these obstacles.

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But I want you to speak to kind of your general perspective.

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And maybe if you want to speak for even your generation to the extent that you can, what

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are the things that you're doing to help us from a younger perspective understand the

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sacrifices and the investments that you're continuing to make to move us forward?

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You know what?

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And you just hit the nail on the head, right?

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There is a level of mission generated that while I think they use a young folks term,

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I'm into myself, there is a danger of being so much into yourself though that you become

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a me as opposed to a we.

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By the same token, the other philosophy of that there is no me, it's all we, right?

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I'm always giving allows for people to be burned out without even knowing.

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So there's this wisdom that interestingly that I've been watching about how do we move

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the needle forward about balance.

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Not balance, lifestyle balance and all this stuff.

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So you can say what you want to say, but at some point, you ain't going to always be balanced.

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Like keeping balanced diet, that takes a lot of strictness and I ain't that strict, right?

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So there's some days I'll be like, you know what?

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I know that pound cake ain't right, but I'm going to eat it.

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That's what's going to happen.

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I'm going to limit it to one, but I'm going to have a slice of that pound cake, right?

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So the reality is that's like life.

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So as we're talking about how do we move things ahead, it is interesting because the formula

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has not changed.

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The formula has not changed.

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It is making sure that we are not only at the table, but having opportunities to set

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the table.

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And what I think we need to do better on is how do we take care of our leaders once they're

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there and then how do the leaders take care of our younger generations as they're moving

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through to open up doors.

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You know, we, you're talking frankly, y'all know what's up.

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I mean, sometimes you get one brother, one sister there, they're like, listen, I'm the

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one.

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You know, what's the rest of y'all, right?

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But then you actually have folks who sort of say we never get to the tables.

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And that's the one thing I think we have to continue to fight.

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How do we do that?

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I do think that there will become a need over the next several years and probably over the

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next six months and certainly over the next year to double down in being deliberate about

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being seen, about being at the committees that are making the decisions.

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And by the way, I've always, you know, this is straight up hood.

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I'm like, if you ain't gonna let me at your table, I'll create a table and we're gonna

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actually come with it enough that you're gonna want to be in mine and then we'll figure it

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out.

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That's right.

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I do think that this sense of, you know, I mean, not to get all barby like and all the

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rest of that, but we do have to wake up to that we have models and we have frameworks

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that have already been shown.

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The problem is that most of those we haven't been passed down and we haven't been taught.

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And so I have made it a deal to make sure that I stay in contact with people like Charles

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Thomas, Theodos Brawley, Lucille Elms-Campbell, Asanya Springfield, the Tom Hage Kings, because

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the reality is that there are frameworks that based on their wisdom that they weren't able

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to do that they would say, if I had an opportunity, here's a model that I would use and I'm, aha.

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So I do think that how we're gonna do it, I think we need to have more intergenerational

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conversations than we are having now.

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And not the kind that are blaming like, ah, you know, I mean, it's true.

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You know, we, our generation, the baby boomers and the Xers were probably much more in line,

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I think, with the experience of having to be super adapters to pain.

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That is one of the elements that I think as an African American that we have actually

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become super or have, for whatever reasons we've had to, right, for survival, have to

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become super adapters to pain, which brings about its own pathology.

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And so I readily admit that.

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However, what I can say is that you can't be crying if somebody ain't letting you in

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the door.

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They're like, that door wasn't meant for you.

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So at some point you like, and then when you get there, you're like, oh, I'm all uncomfortable

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with these people.

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Of course, but I mean, what the hell?

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The dead man's place wasn't made for you.

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We have to get there, set the table and say, this is what we're gonna do and this is how

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I'm gonna do it.

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And to be quite honest with you, the whole concept of black excellence and your authenticity

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in doing it is scary, right?

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Because to make it in those early years, we do have to be able to adapt, not get assimilated.

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You see, I ain't saying get assimilated, because some folks get assimilated so much, you're

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like, well, come on back.

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I wanted to make sure that they understood at all times that the excellence that they

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were seeing is from me.

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And this is the way I came with whatever swag, whether they liked it or not.

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And in fact, people say, have you always quoted hip hop artists?

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I was like, yeah, since the day I was a woman, Tim's and mine was a resident with a bow tie

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and a suit.

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And people were like, those are construction, but I was like, don't call them construction

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boys, they're lieutenants.

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And in fact, I got my clinical Tim's and then I got the Tim's that I wear when I make rouse,

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so they're playing with me, right?

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So that sense of pride of I'm bringing all of me.

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And because when you see that at the end of the day, when I was a resident, I became resident

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of the year or intern of the year, that they also saw that I could learn and be me.

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And there was a sense of liberation in that.

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So how do we get there?

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More conversations, inter-general conversations, but making sure that we are deliberate in

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figuring out what are the committees of impact that when we show up, we not only show out,

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but we make room for other people to bring them up.

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That's what our grandparents taught us.

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The reality is we have had various levels of successes of that because sometimes you

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can get intoxicated once you get to the tables and figure you the one.

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All of a sudden you have all this praise on you, you're this and you're that.

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And then all of a sudden you recognize that you're lonely as hell.

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Because we have not done what our ancestors and what our grandparents and parents taught

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us is that when we come at those tables, we shouldn't just be sitting there.

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We should be setting part of that table up and bringing our folk up with us.

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And I think that that is something that needs to be re-looked at how we can do that.

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And the pride of just sort of saying, I understand people like we're just all human beings and

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I don't see color, but I'm like, well, like Tiger Wood, everybody else sees it except

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for you.

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But I mean, you can do what you want to do.

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But in this state, in this country, people see it.

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So why not embrace it and understand that let's lean into it and say, I am this, but

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also these other things.

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And this level of Andrew's Lord, I think the poet Lord, we talk about all that stuff about

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the intersectionality of things.

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I am more than just being an African-American, but by and large, I want to make sure that

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folk understand that I am that.

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I'm not all of that.

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I'm much more than that.

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I'm the son of people that lived in rural areas and blah, blah, blah.

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All these other things come with it too.

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But the fact of the matter is that that's my income and that's where I start from.

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And so again, you asked me, how do we make this work?

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We know how to make it work.

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We work hard.

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We communicate more.

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We need the network better, and we need to make sure that when we're at the tables, we're

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now already thinking about not only how long you're going to be there, but who else comes

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to follow you.

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And so instead of just bringing one, how do you bring three?

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You know what I'm saying?

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Kanichi was who take you want to meet all day long.

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I love it.

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I also love the analogy is about grandparents.

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Because I think about I'm a parent of young children.

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I think about this a lot.

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I think about the grandparents and they don't have the stress that they had when they were

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parents.

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And so I think it's very difficult to teach the younger generation something that perhaps

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the parents are too busy right now to teach.

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And so I love the idea of the conversations of the older and the younger generation because

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this idea of like, you expected to be taught is something that I do wish people had shared

348
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with me early on.

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So I wouldn't have been surprised when these obstacles came.

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And so I love what you shared.

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And I hope that there are so many more of these opportunities that we can take advantage

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of in making these connections.

353
00:21:16,320 --> 00:21:18,440
Oh, well, thank you so much.

354
00:21:18,440 --> 00:21:21,080
Well, you know, I do think that they're important conversations.

355
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And I got to tell you what trips me out is when I'm somewhere and everybody's nice to

356
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me, I'm like, what the hell?

357
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Stop it.

358
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I mean, hold on.

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I'm like, oh, don't somebody go down.

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I'm like, it's so but that I have to laugh at myself because that is my generation of

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how I grew up.

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Because when you like, yeah, I know that with the exit.

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Yeah.

364
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And my sense of the exit, I mean, sometimes I'll be like, literally a case in the room

365
00:21:48,160 --> 00:21:49,480
these days, like, where's the exit?

366
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So these people be too damn nice.

367
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What's up?

368
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And so it's wonderful, though, to see that we can change.

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But I think that we have the elephant in the room is that we have to recognize that we

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have also live in a generation now where there is a actual push to go backwards.

371
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And part of that is a fear of change, and part of that is a fear that we have not always

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as we've risen, made sure that we made sure that we've made sure that everyone is still

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visible.

374
00:22:21,400 --> 00:22:25,740
We have invisible communities, which is why I work so hard and making sure that as we're

375
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pushing the science and we're pushing the clinical trials and we're pushing these things,

376
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that we also are not locked in into just pushing it for our communities, but making sure that,

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for example, rural underserved communities, which are not just all white, but even those

378
00:22:39,800 --> 00:22:45,360
that are homogeneous white within the eastern parts of Kentucky benefit from our science.

379
00:22:45,360 --> 00:22:49,360
The truth of the matter is that if it only benefits the people that come to my hospital,

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then we fail because most people aren't getting to our hospitals.

381
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And so the question becomes, how do we make communities, just like Brother Hampton said,

382
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that Brother Hampton was one of my...

383
00:23:01,800 --> 00:23:04,120
I mean, listen, I know I'm talking Panther.

384
00:23:04,120 --> 00:23:08,720
But if I had to pick a Panther, it was Fred Hampton because Fred Hampton was the first

385
00:23:08,720 --> 00:23:11,720
that sort of said power to the people.

386
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It wasn't just power to black people.

387
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It was power to the people.

388
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And the first Rainbow Coalition before there was a Jesse Jackson was with Fred Hampton,

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00:23:19,480 --> 00:23:25,140
who understood the power that we all actually have sometimes similar struggles and we should

390
00:23:25,140 --> 00:23:26,400
benefit from those things.

391
00:23:26,400 --> 00:23:30,160
In our case, people should benefit, all people, from our medicines.

392
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And all people should benefit from our research.

393
00:23:32,400 --> 00:23:37,640
And all people should benefit from the molecules that becomes medicines, that become trials,

394
00:23:37,640 --> 00:23:42,160
that become really extension of healthcare to make people's life healthier.

395
00:23:42,160 --> 00:23:45,360
And that philosophy, I think it was not new.

396
00:23:45,360 --> 00:23:49,680
That's not a new 21st century philosophy or post Obama and all the rest of that.

397
00:23:49,680 --> 00:23:53,680
I mean, I never bought it to the post-racial thing anyways, but for sure this wanting to

398
00:23:53,680 --> 00:23:56,880
be that we are the world, we are one is okay.

399
00:23:56,880 --> 00:24:01,520
But understand, we don't have to be all of that and still not be us.

400
00:24:01,520 --> 00:24:06,000
It's my responsibility as a cancer center director to make sure definitely that the

401
00:24:06,000 --> 00:24:11,120
science that I do actually helps hopefully to inspire and hopefully impact African-American

402
00:24:11,120 --> 00:24:12,120
communities.

403
00:24:12,120 --> 00:24:17,120
But if it's not actually hitting Asian communities, Latino communities, rural communities, and

404
00:24:17,120 --> 00:24:24,000
even urban, very rich white communities, then I'm not doing my job.

405
00:24:24,000 --> 00:24:27,320
So this is a wonderful thing of being both, right?

406
00:24:27,320 --> 00:24:30,960
That both can exist at the same time, which I'm really digging.

407
00:24:30,960 --> 00:24:37,800
I think, and you set up the stage perfectly for us to talk now about the Robert Winn Diversity

408
00:24:37,800 --> 00:24:40,000
in Clinical Trials program.

409
00:24:40,000 --> 00:24:42,560
And can you just speak about that program?

410
00:24:42,560 --> 00:24:44,880
How does it fit within all that you've been sharing?

411
00:24:44,880 --> 00:24:45,880
What is this program?

412
00:24:45,880 --> 00:24:51,640
Yeah, I learned from John DeMonte, you know, saying from Maya Angelou, and that is that

413
00:24:51,640 --> 00:24:56,240
to change the system, you just can't do something different.

414
00:24:56,240 --> 00:24:58,540
You have to do a different thing.

415
00:24:58,540 --> 00:25:00,200
So here was the deal.

416
00:25:00,200 --> 00:25:04,520
We know that we have people who are very good people in outreach and engagement, but most

417
00:25:04,520 --> 00:25:10,340
of those folks are not aware of the difficulties and the pain or the knowledge and the expertise

418
00:25:10,340 --> 00:25:13,520
of how do you get a molecule to become a medicine.

419
00:25:13,520 --> 00:25:16,400
So that's a weakness.

420
00:25:16,400 --> 00:25:22,280
Then you have people who are physicians, well-intended clinical trialers who want to make high impact

421
00:25:22,280 --> 00:25:26,640
trials or doing basket trials or pragmatic trials or doing all these things.

422
00:25:26,640 --> 00:25:31,320
But we ain't got no freaking clue about the, I didn't just say outreach and engagement.

423
00:25:31,320 --> 00:25:35,160
I said the science of outreach and engagement.

424
00:25:35,160 --> 00:25:41,600
The program was meant to recognize that there was a big hole since the advent of clinical

425
00:25:41,600 --> 00:25:46,080
trials that we did not develop a quarterback for clinical trials.

426
00:25:46,080 --> 00:25:51,520
And what I mean by that is that someone who had knowledge of both how to design and implement

427
00:25:51,520 --> 00:25:58,160
a high impact trial and also that same person may not have the complete expertise, but was

428
00:25:58,160 --> 00:26:04,560
aware and had some expertise in the science of outreach and engagement.

429
00:26:04,560 --> 00:26:07,120
And why do I say the science of outreach and engagement?

430
00:26:07,120 --> 00:26:11,720
Well the science of outreach and engagement or the science of community-based type approaches

431
00:26:11,720 --> 00:26:15,960
means that it is built on literature, which there's a 40 plus year history on this.

432
00:26:15,960 --> 00:26:21,840
It also is built on frameworks so that when I design and implement my trials, the goal

433
00:26:21,840 --> 00:26:26,760
was to not only have someone design the arm one and arm two and we're going to have these

434
00:26:26,760 --> 00:26:33,640
two arms, but as they're developing their protocols, that at every step of the way,

435
00:26:33,640 --> 00:26:39,200
they're developing also a parallel protocol on how they're going to get more people from

436
00:26:39,200 --> 00:26:41,520
challenged backgrounds onto those studies.

437
00:26:41,520 --> 00:26:46,680
You know, my dream was to actually have one of my scholars, if you will, actually come

438
00:26:46,680 --> 00:26:51,000
up with a protocol that looked like not just here's a protocol of how we get more people

439
00:26:51,000 --> 00:26:56,320
on to clinical trials or say in this case African-American to rural or here's an event

440
00:26:56,320 --> 00:27:01,520
this is my trial, but to imagine a world in which we challenge the entire world of doing

441
00:27:01,520 --> 00:27:03,080
something different.

442
00:27:03,080 --> 00:27:07,840
And we actually meld with those two that as the same time we were actually designing and

443
00:27:07,840 --> 00:27:14,040
implementing a trial for getting rural patients with GLEO, you know, with GBMs, how do we

444
00:27:14,040 --> 00:27:19,360
get them onto trials that we would actually also be solving the problem of, yeah, here's

445
00:27:19,360 --> 00:27:26,160
a wonderful high impact trial for GBMs and other neurocancers, but we were also putting

446
00:27:26,160 --> 00:27:32,520
equal amount of attention to how do we leverage communities to help us get more people on.

447
00:27:32,520 --> 00:27:35,720
How do we connect with primary care doctors?

448
00:27:35,720 --> 00:27:40,560
How by the way, when we communicate, what's the effect of communication?

449
00:27:40,560 --> 00:27:45,180
How do we use asset maps, both functional, which is a new word, functional asset mapping

450
00:27:45,180 --> 00:27:46,520
and asset mapping?

451
00:27:46,520 --> 00:27:52,160
How do we put all of those, so not that it exists in one person, but that they are aware.

452
00:27:52,160 --> 00:27:57,000
For example, a quarterback of a team or a point guard has to know all the other positions,

453
00:27:57,000 --> 00:28:02,000
they don't play all the other positions, but they have to be aware of how things work so

454
00:28:02,000 --> 00:28:04,920
that they can get from point A to point B to make a play.

455
00:28:04,920 --> 00:28:12,120
We did not have that person in any of our clinical training period.

456
00:28:12,120 --> 00:28:18,280
So I said, well, since I don't see it, I ain't asking no questions, let's just do it.

457
00:28:18,280 --> 00:28:21,800
And in fact, people would say, well, that's, wow, that's going to be a lot of work and

458
00:28:21,800 --> 00:28:22,800
it's crazy.

459
00:28:22,800 --> 00:28:27,220
You're like, yeah, it's a lot of work, but every big thing is going to be a lot of work.

460
00:28:27,220 --> 00:28:30,920
So it really is trying to make sure that the first and the second and the third pancakes,

461
00:28:30,920 --> 00:28:35,560
they get better and better with iteration on what does it look like when you have someone

462
00:28:35,560 --> 00:28:40,320
who actually not only understands regulatory and how to get things from a molecule to a

463
00:28:40,320 --> 00:28:44,920
medicine into a trial and all the arms of a trial, but also they're understanding the

464
00:28:44,920 --> 00:28:50,240
difficulty and saying, yep, this is what we'll have to do operationally and from a protocol

465
00:28:50,240 --> 00:28:55,680
wise for this trial to actually have this percentage or to have this many people from

466
00:28:55,680 --> 00:28:56,920
the rural area.

467
00:28:56,920 --> 00:29:01,200
This is what I'm going to have to integrate into my protocol and take into account to

468
00:29:01,200 --> 00:29:02,840
get that outcome.

469
00:29:02,840 --> 00:29:06,960
Now that is a new idea.

470
00:29:06,960 --> 00:29:10,240
Back in the old days, up in the 80s and 90s, we'd be saying like, that's fat, but I'm going

471
00:29:10,240 --> 00:29:11,720
to be like, yo, that's hot.

472
00:29:11,720 --> 00:29:13,640
So that's what we're going for.

473
00:29:13,640 --> 00:29:16,520
Now the reality is, will we get there immediately?

474
00:29:16,520 --> 00:29:17,520
We won't.

475
00:29:17,520 --> 00:29:22,120
But just like everything, to get to the moon or to get to immunotherapy, nobody cries and

476
00:29:22,120 --> 00:29:28,720
we talk about it took 125 years from Cooley to all these other things to get to the checkpoint

477
00:29:28,720 --> 00:29:32,800
inhibitors, nobody cried that it took 125 years and there were some setbacks.

478
00:29:32,800 --> 00:29:40,200
So quit playing with me that this concept of having a group of, for the first time,

479
00:29:40,200 --> 00:29:46,280
first trained people in the country and maybe actually in the world, because I've checked,

480
00:29:46,280 --> 00:29:51,600
who are being taught and tried to train and what happens when you are skilled and you

481
00:29:51,600 --> 00:29:55,360
have two kids and extra teeth in both, what happens?

482
00:29:55,360 --> 00:29:58,480
I think it's going to be a game changer.

483
00:29:58,480 --> 00:30:03,560
That's going to take a while, but that's why, look here, Dr. Ode, this is why I'm so proud

484
00:30:03,560 --> 00:30:04,560
of you.

485
00:30:04,560 --> 00:30:08,200
I'm like, girl, listen, listen, you don't know how, look, I'm smiling ear to ear.

486
00:30:08,200 --> 00:30:09,200
My heart, you know what I'm saying?

487
00:30:09,200 --> 00:30:15,120
It's big, I'm just saying, because y'all will make the difference and be the game changers

488
00:30:15,120 --> 00:30:19,240
and really sort of set it off in a way that I'm just excited about seeing how that's going

489
00:30:19,240 --> 00:30:20,240
to go down.

490
00:30:20,240 --> 00:30:23,200
I'm excited to be part of the program.

491
00:30:23,200 --> 00:30:27,320
I thank you for your vision and building it together, because one of the things that I

492
00:30:27,320 --> 00:30:34,080
see is that there is an expectation that clinicians are going to finish clinical training and

493
00:30:34,080 --> 00:30:39,520
then all of a sudden be experts in research and not even to talk about being the science

494
00:30:39,520 --> 00:30:41,120
of community engagement.

495
00:30:41,120 --> 00:30:43,040
And I love that you emphasize that as well.

496
00:30:43,040 --> 00:30:46,720
It's like, well, clinical training should be about clinical training, but then the next

497
00:30:46,720 --> 00:30:52,000
step of training so that we can build diversity in clinical trials, actually it needs to happen.

498
00:30:52,000 --> 00:30:57,560
And so it's almost like, you know, the program is novel, it's amazing.

499
00:30:57,560 --> 00:31:01,280
And it's also like, but why haven't we been doing this all along?

500
00:31:01,280 --> 00:31:05,440
Why have we assumed that it was just all going to work out?

501
00:31:05,440 --> 00:31:08,240
And so I just want to thank you.

502
00:31:08,240 --> 00:31:10,400
You're a trailblazer in so many ways.

503
00:31:10,400 --> 00:31:16,280
And I mean, thank you.

504
00:31:16,280 --> 00:31:17,280
You know what I want to say?

505
00:31:17,280 --> 00:31:22,080
I want to say you're not just reaching out, you're not just reaching physicians, you're

506
00:31:22,080 --> 00:31:23,760
going further back.

507
00:31:23,760 --> 00:31:26,560
Talk about the CIPP pathway.

508
00:31:26,560 --> 00:31:30,800
Well, you know, it's going to be, you know, the reality is this is all about the phase

509
00:31:30,800 --> 00:31:31,800
game.

510
00:31:31,800 --> 00:31:33,240
So we have it moving forward and moving back.

511
00:31:33,240 --> 00:31:37,040
We actually recognize, and at some point we'll get into the high schools and middle schools,

512
00:31:37,040 --> 00:31:40,500
but you know, right now you got to take a step at a time when you're building this program.

513
00:31:40,500 --> 00:31:44,520
We have a component of taking those young, those young minds, people in medical school

514
00:31:44,520 --> 00:31:48,360
who haven't even thought about careers in oncology or haven't thought about careers

515
00:31:48,360 --> 00:31:51,760
in cardiology or haven't even thought about being clinical trialists.

516
00:31:51,760 --> 00:31:57,000
They just, and being able to expose them to you guys and expose them to the science and

517
00:31:57,000 --> 00:32:01,840
expose them to the importance of having a life of academic relevance.

518
00:32:01,840 --> 00:32:07,040
I say the people that my first half of my life was signatured by just pursuing academic

519
00:32:07,040 --> 00:32:09,240
excellence because that's what I was taught.

520
00:32:09,240 --> 00:32:12,960
But at some point I had to transition from chasing academic excellence and making that

521
00:32:12,960 --> 00:32:18,880
excellence turn into being academically relevant and ultimately looking at just from innovation

522
00:32:18,880 --> 00:32:22,040
to actually having a life of impact.

523
00:32:22,040 --> 00:32:25,040
And when you start putting that in front of these young people, and all of a sudden light

524
00:32:25,040 --> 00:32:28,320
bulbs go on and that's like the most amazing thing to see.

525
00:32:28,320 --> 00:32:32,080
By the way, the wonderful thing about this program is that it's growing in ways, leaps

526
00:32:32,080 --> 00:32:34,840
and bounds that I did not expect, you know, when I came out with this.

527
00:32:34,840 --> 00:32:38,720
I mean, sometimes, you know, some of y'all didn't know that this was supposed to be only

528
00:32:38,720 --> 00:32:41,040
a pilot grant for VCU.

529
00:32:41,040 --> 00:32:42,600
That's how it started.

530
00:32:42,600 --> 00:32:47,680
And then after George Floyd, John DeMonte, who is from Bristol Mines Squibb Foundation,

531
00:32:47,680 --> 00:32:51,680
called me up and said, Dr. Wynn, we need to go big.

532
00:32:51,680 --> 00:32:52,880
And we did.

533
00:32:52,880 --> 00:32:55,880
By the way, that's one of the people you want to talk about a game changer when it comes

534
00:32:55,880 --> 00:33:00,480
in the context of Canton, the context of how foundations can give resources to change the

535
00:33:00,480 --> 00:33:01,480
world.

536
00:33:01,480 --> 00:33:05,720
Before there was a PEPFAR and all the rest of these things, there was a John DeMonte

537
00:33:05,720 --> 00:33:12,080
who got Bristol Mines Squibb Foundation before there was anyone else to actually get into

538
00:33:12,080 --> 00:33:15,840
Africa and give HIV drugs and figure out how to do that.

539
00:33:15,840 --> 00:33:16,840
That was John.

540
00:33:16,840 --> 00:33:22,520
And in fact, there have been several prime ministers who've gotten up and said that John

541
00:33:22,520 --> 00:33:29,360
DeMonte from Bristol Mines Squibb Foundation has saved generations of young Africans because

542
00:33:29,360 --> 00:33:30,360
of his work.

543
00:33:30,360 --> 00:33:33,640
There are men like that that come in your life and people like that, Catherine Grimes,

544
00:33:33,640 --> 00:33:39,120
John DeMonte and others who come into your life who you just sort of say, yo, let's go

545
00:33:39,120 --> 00:33:40,820
do this.

546
00:33:40,820 --> 00:33:47,300
So in addition to having a medical student program, we now have for the Wynn CDA scholars

547
00:33:47,300 --> 00:33:54,800
another three-year program and being part of what we call the cooperative group trials

548
00:33:54,800 --> 00:33:57,280
and cancer cooperative group trials.

549
00:33:57,280 --> 00:34:01,920
Also we have now developing with a group of cardiology within the AHA that there's an

550
00:34:01,920 --> 00:34:05,000
additional three years of additional training.

551
00:34:05,000 --> 00:34:09,200
And we're about to actually play with the concept of we know people are going on a form

552
00:34:09,200 --> 00:34:11,960
of two, how do we give opportunities and exposure to that?

553
00:34:11,960 --> 00:34:18,040
So my job is really just to say we about training the next generation with one caveat that I'm

554
00:34:18,040 --> 00:34:21,240
not just training somebody who just do clinical trials.

555
00:34:21,240 --> 00:34:24,600
We talk in clinical trials plus.

556
00:34:24,600 --> 00:34:30,560
And the plus is how do we get the best, most effective clinical trials and how do we get

557
00:34:30,560 --> 00:34:37,240
the most number of people from diverse backgrounds onto those trials?

558
00:34:37,240 --> 00:34:40,880
And that is a science and that is a skill set.

559
00:34:40,880 --> 00:34:45,320
And that is something that as you guys even perfect, I think that you will be the first

560
00:34:45,320 --> 00:34:51,020
generation of people who will be widely recruited in the context of your ability to do that.

561
00:34:51,020 --> 00:34:52,020
Because you know what?

562
00:34:52,020 --> 00:34:56,280
Turns out the FDA and other people are going to expect big pharma companies and others

563
00:34:56,280 --> 00:34:58,460
to actually have diversity on a clinical trial.

564
00:34:58,460 --> 00:35:03,220
So interesting, it's building the workforce that we are going to need for tomorrow.

565
00:35:03,220 --> 00:35:05,440
That's the best part of this.

566
00:35:05,440 --> 00:35:06,440
That's beautiful.

567
00:35:06,440 --> 00:35:09,000
That's so awesome.

568
00:35:09,000 --> 00:35:11,000
And the innovation of it is awesome.

569
00:35:11,000 --> 00:35:15,800
Actually, as you were talking, I'm like, you're kind of building the bridge as you are like

570
00:35:15,800 --> 00:35:17,800
speeding on it.

571
00:35:17,800 --> 00:35:20,800
But I got y'all.

572
00:35:20,800 --> 00:35:21,800
Y'all make me look good.

573
00:35:21,800 --> 00:35:24,120
Y'all be coming up with these trials.

574
00:35:24,120 --> 00:35:29,120
The other day I saw I was actually one of the scholars was actually doing his work and

575
00:35:29,120 --> 00:35:34,280
he said, and so I automatically had this thing about I wanted to get more African Americans

576
00:35:34,280 --> 00:35:38,000
on it because this trial of prostate cancer until in my head I was doing this protocol.

577
00:35:38,000 --> 00:35:40,880
And so I integrated the protocol with my protocol.

578
00:35:40,880 --> 00:35:45,160
Now I don't show that to you know the drug, but I'm just showing you Dr. Wynn that here's

579
00:35:45,160 --> 00:35:48,200
from the very first step I was like, well, these neighborhoods I've had obstacles and

580
00:35:48,200 --> 00:35:49,840
so this is what I've not needed to do.

581
00:35:49,840 --> 00:35:51,880
And I said, you should write a paper about that.

582
00:35:51,880 --> 00:35:54,640
That is the beauty of what's going down.

583
00:35:54,640 --> 00:35:55,640
Yeah.

584
00:35:55,640 --> 00:35:56,640
Yeah.

585
00:35:56,640 --> 00:35:57,640
Y'all doing it.

586
00:35:57,640 --> 00:36:00,360
You know me, I'm just, you know, I just, you know, I set it up.

587
00:36:00,360 --> 00:36:02,440
I ain't the one, you know, I like Moses.

588
00:36:02,440 --> 00:36:04,440
I ain't going to get to the promised land with y'all.

589
00:36:04,440 --> 00:36:07,960
Y'all gonna get there, but I'm going to be so proud when you do.

590
00:36:07,960 --> 00:36:12,720
And it's, it's what you're speaking to is that just the power of community and all our

591
00:36:12,720 --> 00:36:16,320
different roles, but how important we all are in moving the workforce.

592
00:36:16,320 --> 00:36:17,320
No, it's phenomenal.

593
00:36:17,320 --> 00:36:19,320
I'm telling you it's like Wu-Tang.

594
00:36:19,320 --> 00:36:20,320
It ain't about me.

595
00:36:20,320 --> 00:36:21,320
It's Wu-Tang.

596
00:36:21,320 --> 00:36:22,320
Oh, he talk about all day.

597
00:36:22,320 --> 00:36:28,440
Oh, Dr. Wynn, it's been, it's been such a pleasure talking with you.

598
00:36:28,440 --> 00:36:29,920
We're coming to the end of the show.

599
00:36:29,920 --> 00:36:33,920
And I want to ask you, we've said a lot and then there are things we haven't even talked

600
00:36:33,920 --> 00:36:38,880
about, but you know, just thinking about just wrapping up our conversation.

601
00:36:38,880 --> 00:36:46,280
What is one thing that you feel like is left unsaid that you want to share with our audience?

602
00:36:46,280 --> 00:36:48,880
Drake started from the bottom.

603
00:36:48,880 --> 00:36:49,880
Now we're here.

604
00:36:49,880 --> 00:36:50,880
You know what I'm saying?

605
00:36:50,880 --> 00:36:53,680
He started from the bottom, now the whole crew's here.

606
00:36:53,680 --> 00:36:54,920
Like let's rise.

607
00:36:54,920 --> 00:36:56,240
We turning it up.

608
00:36:56,240 --> 00:36:57,240
Let's make it happen.

609
00:36:57,240 --> 00:37:01,560
And the reality is I ain't worried about a little white noise and all the other stuff

610
00:37:01,560 --> 00:37:02,800
and the distractions.

611
00:37:02,800 --> 00:37:03,920
Let's get focused.

612
00:37:03,920 --> 00:37:04,920
Let's get locked in.

613
00:37:04,920 --> 00:37:09,960
Let's understand that the success that we have is being watched and the success we have

614
00:37:09,960 --> 00:37:12,320
will build on other successes of the future.

615
00:37:12,320 --> 00:37:16,320
And in fact, to do that, one must have courage.

616
00:37:16,320 --> 00:37:19,600
And with courage comes vulnerability and sometimes risk.

617
00:37:19,600 --> 00:37:20,940
But so what?

618
00:37:20,940 --> 00:37:24,960
Because if somebody had to have courage for us to get us this far, somebody had to have

619
00:37:24,960 --> 00:37:28,860
the courage to say something to make sure that our medical schools and our residencies

620
00:37:28,860 --> 00:37:30,400
and our fellowships are better.

621
00:37:30,400 --> 00:37:32,100
Let's continue that courage.

622
00:37:32,100 --> 00:37:33,100
You know what I mean?

623
00:37:33,100 --> 00:37:35,320
Stand up, stand strong, show up.

624
00:37:35,320 --> 00:37:36,320
Let's do it.

625
00:37:36,320 --> 00:37:40,480
Because actually our people in our communities are banking on the fact that we can do this.

626
00:37:40,480 --> 00:37:44,680
So you know, I'm just like, let's get it done.

627
00:37:44,680 --> 00:37:46,600
That's a perfect place to end.

628
00:37:46,600 --> 00:37:49,240
And I feel like you should stand up now and take a bow.

629
00:37:49,240 --> 00:37:54,640
Girl, look, I'm just a little fella trying to do a little something.

630
00:37:54,640 --> 00:37:55,640
So that's all.

631
00:37:55,640 --> 00:37:58,560
Dr. Nguyen, thank you so much for being on the show.

632
00:37:58,560 --> 00:38:00,680
It's been a pleasure to have you.

633
00:38:00,680 --> 00:38:01,680
You know what?

634
00:38:01,680 --> 00:38:02,680
Thank you for having me.

635
00:38:02,680 --> 00:38:06,920
You know, much respect and I'm honored to be on the show and looking forward to the

636
00:38:06,920 --> 00:38:08,720
great things that you're going to do.

637
00:38:08,720 --> 00:38:09,720
Thanks, Dr. Nguyen.

638
00:38:09,720 --> 00:38:10,720
All right, everybody.

639
00:38:10,720 --> 00:38:22,120
We'll see you next time on the Clinician Researcher podcast.

640
00:38:22,120 --> 00:38:27,480
Thanks for listening to this episode of the Clinician Researcher podcast, where academic

641
00:38:27,480 --> 00:38:32,920
clinicians learn the skills to build their own research program, whether or not they

642
00:38:32,920 --> 00:38:34,280
have a mentor.

643
00:38:34,280 --> 00:38:40,240
If you found the information in this episode to be helpful, don't keep it all to yourself.

644
00:38:40,240 --> 00:38:42,120
Someone else needs to hear it.

645
00:38:42,120 --> 00:38:46,160
So take a minute right now and share it.

646
00:38:46,160 --> 00:38:51,640
As you share this episode, you become part of our mission to help launch a new generation

647
00:38:51,640 --> 00:38:57,600
of clinician researchers who make transformative discoveries that change the way we do healthcare.

Robert Winn Profile Photo

Robert Winn

Director

As director of VCU Massey Comprehensive Cancer Center, Robert A. Winn, M.D., oversees a cancer center designated by the National Cancer Institute that provides advanced cancer care, conducts groundbreaking research to discover new therapies for cancer, offers high-quality education and training, and engages with the community to make advancements in cancer treatment and prevention equally available to all. He is leading the nation in establishing a 21st-century model of equity for cancer science and care, in which the community is informing and partnering with Massey on its research to best address the cancer burden and disparities of those the cancer center serves, with a local focus but global impact.
His current basic science research, which has been supported by multiple National Institutes of Health and Veterans Affairs Merit awards, focuses on the molecular mechanisms and novel therapeutic approaches for human models of lung cancer. He has authored or co-authored more than 80 published manuscripts in peer-reviewed academic journals.