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Sept. 29, 2023

Journey to research excellence with Dr. Julia Xu

Journey to research excellence with Dr. Julia Xu
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Clinician Researcher

Dr. Xu is an adult hematologist specializing in the care of patients with sickle cell disease (SCD). She has conducted studies of the trajectory of renal function decline in SCD and led clinical trials evaluating novel drug therapies for the treatment of patients with SCD. She has a longstanding interest in both red cell disorders and global health, having completed combined internal medicine-global health residency training and a Master of Science in Global health degree.In today's episode, Dr. Xu provides insights into the following keys:

  1. The power of focus

  2. The importance of balancing clinical and research roles

  3. Seizing opportunities for leadership

  4. Growing through challenges

  5. Crafting a negotiation strategy

  6. Becoming a bold negotiator

  7. The power of mentorship

From dr. Xu, we can discover the nuances of the clinician researcher transition and glean valuable insights from a young and accomplished clinician researcher.Are you ready to unlock the power of negotiation to boost your compensation and amplify your research impact? If yes, sign up for Academic Negotiation Academy today: https://www.coagcoach.com/negotiation.

Transcript

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Welcome to the Clinician Researcher podcast, where academic clinicians learn the skills

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to build their own research program, whether or not they have a mentor.

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As clinicians, we spend a decade or more as trainees learning to take care of patients.

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When we finally start our careers, we want to build research programs, but then we find

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that our years of clinical training did not adequately prepare us to lead our research

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program.

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Through no fault of our own, we struggle to find mentors, and when we can't, we quit.

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However, clinicians hold the keys to the greatest research breakthroughs.

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For this reason, the Clinician Researcher podcast exists to give academic clinicians

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the tools to build their own research program, whether or not they have a mentor.

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Now introducing your host, Toyosi Onwuemene.

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Hello everyone, and welcome to the Clinician Researcher podcast.

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I'm your host, Toyosi Onwuemene, and it's such a pleasure to be here with you today.

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I'm extremely excited about today's episode because we have a really thoughtful guest,

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Julia Xu, who is going to introduce herself shortly, but she's an outstanding clinician

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researcher who's really making waves in the field, and I want you to meet her.

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So without further ado, I'm going to say, Julia, welcome to the show.

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Thank you so much for having me.

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I'm really happy to be on the show.

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And just by way of introduction, I guess I'll just briefly say that I am currently an assistant

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professor at University of Pittsburgh in the Department of Medicine, Division of Hematology

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Oncology and Section of Benign Hematology, I see patients with benign hematological conditions,

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but mostly focusing on sickle cell disease and other hemoglobin disorders, and I'm adult

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internal medicine and global health trained as well.

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And then I also do clinical research, have a couple of clinical trials ongoing, and also

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have a small lab.

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So I think that's why I'm here to talk about both the clinical and the research portion

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of careers.

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Thank you, Julia.

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That's an awesome introduction.

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I chuckled when you said you have a small lab, because I feel like it, you know, I think

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it's important.

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I'm going to ask you to tell us how many years out you are from your fellowship, so how many

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years you are into this junior faculty career, and then ask you about, like, at what point

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did you decide, hey, I'm a clinician scientist, I'm a clinician researcher.

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At what point did you feel like you owned the position?

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Because you're a little early in your career, I feel, and have accomplished so much that

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I wonder if you can speak to that.

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Of course, and thank you, very kind words.

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So I am about a year and a half out from fellowship.

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So I did my hematology only fellowship at the National Institutes of Health at the NIH.

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I did a one year hematology fellowship followed by a couple of years of research, and then

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during my transition period stayed on a little bit longer to finish some research transition

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to University of Pittsburgh in October of 2021.

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And so I'm kind of in my second year of the faculty position and getting settled in, you

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know, getting studies off the ground, getting the lab finally set up.

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And so you're right, I am pretty early in my research career still.

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I would say I, gosh, owning is a hard concept, because sometimes I feel like I still don't

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own that identity.

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You know, there's always a lot of imposter syndrome and second guessing yourself in this

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career track.

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But I think I felt like a physician researcher when I was in residency at first, because

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I did a global health fellowship where I had a year to conduct independent research internationally

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in Thailand.

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And I think that that was kind of the first time that I was the PI of a project and I

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was, you know, managing an international grant and collaboration and, you know, could really

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say like, okay, I have taken charge of this research project and it is on me whether it

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was or dies.

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And then during my fellowship training, had the opportunity to lead a couple of early

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phase clinical trials and that really cemented my, I guess, confidence that I was able to

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assume more of a leadership position rather than someone who was carrying out research

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on behalf of a mentor.

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And so I think those experiences were probably the most formative, even though all of the

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research experiences I had up to that point had really built upon each other and kind

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of gave me a little bit more confidence step by step.

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Thank you for sharing that piece of your story.

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You know, it's funny, every time I hear your story, I think, wow, what an accomplished

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person.

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You've been doing so much for so long.

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It's interesting, you know, you talk about you leading a research program as a resident.

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Okay.

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So I'm going to pause and just say that most of the time that doesn't happen, right?

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Many clinicians going through training are participating in programs.

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They're not leading and you are not just leading in programs, you're leading a research program

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internationally and managing collaborations, which is such a great experience for you to

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have.

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I think many, many times there isn't really in our training and our clinical training,

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especially we have a little bit of research here and there, but opportunities to actually

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be in leadership of research don't necessarily happen commonly.

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So I do want to pause there and ask, what was the set of circumstances in your life

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that allowed you as a resident to lead this research program?

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How did that come to be?

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Yeah, I know that's a really good point.

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And I feel lucky in so many ways to have been put on this trajectory early.

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I think at the end of the day, you know, if you want to do research, I think getting into

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it early really lets you reap the rewards afterwards.

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And every little success begins further success in the academic career track.

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So I started off doing lab-based research in college, got a master's degree with a program.

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I was at University of Pennsylvania and there's a program called Vagilist Scholars Program,

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which allows you to sub-matriculate.

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And so it paid for two summers of full-time summer research and time during the year to

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work on your research and master's project.

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And so that gave me lab experience, you know, got me on my first co-author publication,

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but also made me realize that I didn't want to be just a basic scientist.

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I think I really missed the clinical side of things.

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I really liked translating discoveries.

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And even though I was fascinated by the lab work, I just didn't see myself as the PI of

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a large lab.

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And so I actually kind of used that experience to decide to go into medical school.

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And then during medical school, you know, I had some research experiences here and there.

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Like after my first year of med school, I went to Peru where I did some HIV research,

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but it didn't really pan out.

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You know, nothing came of the project and I ended up spending most of the time shadowing

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and exploring Peru, of course.

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And then, you know, I was really fascinated by the idea of global health and I love Spanish.

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It was kind of my, it was one of my majors in college and just a real passion.

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And so I sought to do more work in Latin America and I stumbled upon this wonderful opportunity

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to work with an amazing team of mentors.

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So I was in Steve's Vitality Lab.

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He's a transfusion medicine professor and he, you know, was a phenomenal mentor, got

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me interested in G6PD deficiency.

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I was kind of leaning towards hematology at the time, but, you know, hadn't decided on

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benign hematology, malignant hematology, you know, oncology.

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But, you know, got me really interested in hemoglobin disorders.

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I think it started my interest in sickle cell there as well.

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And then I had an opportunity to design this project as a, it was supposed to be a three

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month scholarly project, but the more we talked about it, the more we realized if I'm going

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to go, and this was in collaboration with a HIV clinic in the Dominican Republic.

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So it's like, if I'm going to go to the Dominican Republic and I only have three months to get

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a project off the ground, you know, best case scenario, I start it and then it never gets

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finished.

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And so after thinking about it a little more, I decided to apply for a Doris Duke Charitable

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Foundation Award for medical students to have a year of protected time doing research.

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So I used the scholarly project period to write my IRB, and then I spent that next year

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between third and fourth year of medical school going back and forth between the DR and New

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York implementing this project of G6PD deficiency screening and trying to identify risk factors

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that you can use in a low cost algorithm and resource poor settings to screen patients

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with G6PD deficiency.

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And it was a tremendous experience.

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You know, I loved, even though it was a mentored project, but I was the one on the ground kind

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of implementing the study, right?

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So in a way I got my first taste of leadership and, you know, the trials and tribulations

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of trying to see a project through identifying and overcoming barriers, getting people excited

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and engaged in the science.

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I had to figure out how to do all of that in Spanish, which was such a cool experience.

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And so that gave me my first taste of like, kind of leading a research project on the

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ground.

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And then when I came to Duke, you know, one of the reasons that I chose Duke was that

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there's this internal medicine global health residency program that's combined basically

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four years where you do your residency, but then you also do a master's in global health.

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And then you have a year on the ground where you're implementing your own projects and

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usually apply for some sort of grant.

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Like I applied for a Fogarty International Center fellowship.

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And so that gave me the opportunity not only to do research locally, you know, Marilyn

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Tellen, I love her.

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She's an incredible mentor.

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So she was my main mentor at Duke in sickle cell.

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And I kind of sought out working with her specifically in sickle cell.

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We did a really great database project together that, you know, she gave me a lot of independence

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to kind of help lead and direct as well.

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And then she supported me when I went abroad to do a project on balacemia.

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And I think in this situation, I was looking for something in sickle cell and global health,

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and there was just not the right project that fit.

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And so I ended up deciding to make the pivot to study something related, you know, hemoglobin

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disorders, but in kind of a different area of expertise in order to get the knowledge

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and training and experience of leading an independent study.

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And so I think that was one of my better decisions in life to, you know, not just stick with

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exactly my topic area, but to pursue something that gave me the skills I needed to then move

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on to the next step.

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And I think that was really helpful.

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When I then transitioned to fellowship, it could say, hey, I've led a couple of studies

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already.

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I know how to assemble a research team, how to oversee coordinators and interpreters,

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et cetera, and further extended my skill set by helping to run this clinical trial at the

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NIH.

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So a lot of baby steps along the way and a lot of lessons learned, I think.

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And I think at every step, I look for the opportunity that most gave me independence

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and the skill sets that I thought were useful for the future.

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That's super awesome.

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Thank you for sharing your story.

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And I see there, you know, you talk about, actually, you use the word luck at some point

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and you also talk about opportunity.

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But I do see you as someone who was always prepared to take on opportunities when they

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came.

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And I think you also talk about luck meets preparation.

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I feel like that's just such a great piece of your story where you've always had a great

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sense of what you want and you've always gone after it.

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And yes, you've had opportunities where you've had mentors who have allowed you to lead projects,

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but you really have seen yourself as a leader from the beginning and you've taken, you've

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pursued opportunities and you've also been prepared to take them and lead them as they

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come up, which I think is so incredible.

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I think so many people want to be there, you know, five years into faculty or 10 years

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into faculty, but you really started doing that super early.

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And I just want to say kudos to you for doing that.

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You know, I want to ask, is there, is there, because one of the things that I think you

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mentioned earlier is that if you are interested in the teachers start early and you have the

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opportunity to do that, I just wonder what was the earliest experience that made you

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decide I want to try this thing as a researcher, right?

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It just, I wonder what was the earliest experience that led you down this pathway?

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Yeah, I think the earliest experience was probably the project on G6PD inefficiency

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during medical school, you know, having the chance to really troubleshoot your own study.

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Like it's, it is frustrating to no end and also the biggest sense of accomplishment you

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can feel, you know, at the end of the year, realizing like, wow, I just overcome, you

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know, overcame so many hurdles and enrolled like 250 patients in this, you know, survey

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and genotype study.

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And I got all this data and a publication out of it.

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It's really exciting to be able to do that.

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I agree, I do think you have to be in the mindset of taking opportunities as they come

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along, being flexible, you know, things in research never go the way you imagine.

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So you just adapt and roll with the punches and you just have to persevere because I think

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if you, if you're waiting for someone to map out exactly how to do a research project and

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you know, help you along every time you face a hurdle, you'll just never get anywhere because

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everyone's busy with their own stuff.

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And so if you want to lead you, you really have to kind of take the ownership of, you

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know, whatever issues come up and just be tenacious and, you know, keep pushing regardless

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of how desperate the situation seems.

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And it's definitely seemed very desperate at times for me, but you know, in the end,

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it always seems to work out.

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So I think that was probably, you know, my first lesson in like what it truly means to

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engage in research and especially global health research, which comes with its own set of

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challenges.

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And then I think what convinced me to be like, to truly pursue the academic path and be a

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physician researcher or, you know, a physician scientist was my experience leading clinical

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trials at the NIH because I think that's when you get a real feel for like, okay, this is

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not a fellowship project.

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I'm not ticking off a box like this is real research that's going to impact patient care.

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And I can see how to, you know, move this forward into additional lines of research.

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And I think that's really exciting and starting to generate your own ideas about what you

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want to accomplish in the field.

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I love it.

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And you know, for those of you who are listening, Julia is smiling as she's talking about all

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these challenges that she's going through.

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And Julia, it makes me think, you know, sometimes it's not even about the end result.

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Oh, you accrued to an inoculation, so the study and you were able to get a publication.

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I mean, it's great that you have that.

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And that's the tangible piece that lets people know that she did something.

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But you know, as you're smiling, it makes me think that it's who you have to become

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to pull that off.

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That is so rewarding because the Julia that started the, you know, that started the project

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and the Julia that ended the project were two different Julias.

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It was a Julia who had pushed through obstacles, who had stayed tenacious and requested what

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she wanted and firmly pushed things forward.

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I mean, you were just, it was just the transformation that happened inside you that allowed you to

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that is your reward, your personal reward.

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Like the paper is great, but there's a personal reward and the reward in the transformation

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that happens that allows you at the end of that to say, well, what's next?

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What else can I do?

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And I see that in your story, there's almost like a sense of a graduated responsibility,

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so to speak, like a graduated, okay, I've done this project.

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Now I'm moving to the next project.

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And now I'm moving into this dynamic of it.

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Now I'm leading a clinical trial as a fellow.

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Many fellows don't do that, but you've had all these building blocks along the way that

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have allowed you to move forward into the next challenge and the next challenge and

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the next challenge after that.

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And I'm wondering how that lands for you.

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No, I completely agree with you.

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I mean, I think to jump, I think, you know, for instance, it's really intimidating to

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become junior faculty all of a sudden and not have been, you know, led your own studies

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previously and now suddenly all of the onus is on you, right?

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Like it's, it's one of those challenges and I still face it today, but I think I'm much

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more prepared because I had had those previous building blocks before.

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And I think I can say that for each step of my training, like I would not have been comfortable

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leading an international, you know, collaboration as a resident if I had not already gone through

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the many challenges of running an international study as a medical student.

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And you know, maybe I wouldn't have been as prepared for working in a different culture

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and you know, a different environment that I had to adapt to if I hadn't had the experience

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of trying to navigate and negotiate the culture in Peru, even, you know, when I didn't have

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a successful research project, but I still had to learn how to conduct myself in a new

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culture with new colleagues.

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And so I think every experience definitely helps you grow as a person.

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And it also just gives you confidence, you know, for yourself, but also when you're talking

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to other people, because for instance, I think, you know, mentors are also looking for individuals

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who are competent and inspired and, you know, really dedicated.

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And if you can show that through your previous work, you get more people interested in you

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and they're more willing to invest, they're more willing to trust and give you independence

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to kind of let you go on to the next step.

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Because if you've never shown initiative, they might not feel comfortable saying like,

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okay, why don't you take the initiative on this next project?

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So I think it really helps, you know, both ways kind of internally and then also in your

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interactions to be able to say like, yeah, I am ready for the next thing now.

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I love it.

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I love how you kind of highlight the fact that all along you were building a portfolio

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and you're like, this is, I can do this because I have done it.

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I've done it in this phase, I've done it in this place.

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And now I'm ready for the next step.

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I'm ready to be a leader of my own research program.

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And that leads me to think about how you really did as you were transitioning from fellows

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to faculty, you did need to negotiate resources to allow you to succeed in your career.

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And I wonder if you don't mind just sharing with us some of the thoughts that went into

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negotiating or getting ready to negotiate what was your first faculty job.

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Sure.

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And I have to say that was definitely one of the most stressful periods of my life today.

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I'm sure there will be more stressful ones down the road, but it's no one teaches you

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how to negotiate, right?

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And it's such a black box depending on, you know, what you're looking for and which institutions

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are hiring at which time, you know, what they're looking for.

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It's really hard to know what you're even allowed to ask for.

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So I relied on a lot of resources.

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I actually, you know, didn't, I didn't anticipate starting my job search as early as I did.

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I was going to stay on for a little bit longer, but you know, there were institutions that

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were interested in positions that were open and I ended up kind of just kickstarting the

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job search by talking to different people about my career interests.

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You know, not phrasing it as do you have a job for me, but more as I would love to get

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your advice as a leader in the sickle cell field to understand, you know, what my career

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trajectory might look like and what you think is important for me in the next stages, you

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know, my career.

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What's an IV looking for?

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And I got so much good advice that way and also a few job offers along the way.

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And so I think reaching out to different people, you know, experts in the field, people you

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admire is really important.

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As I talked to people, I got more, I began to shape the image of who I wanted to become

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as junior faculty.

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And I think that was really helpful in negotiations, being able to present a concrete image of,

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you know, this is what I intend to do as junior faculty.

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This is the space that I can occupy.

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This is what I can bring to the institution.

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I think plays really strongly when you're negotiating.

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And then all of the other pieces of negotiation, like, you know, it's important to negotiate

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salary.

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Everyone knows that, but more importantly, if you're trying to, you know, shoot for an

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academic career, the two things I think about are protected time and a startup package.

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Because if you don't have time and you don't have money to do the research, you're just

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never going to get the research off the ground.

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And you know, you're going to drown in clinical responsibilities.

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And it's happened to so many people.

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And so I kind of had to first decide what my one and, you know, number one and number

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two priorities were.

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And they were number one, protected time, and then the number two, you know, the resources

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that I got starting out.

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And so, you know, protected time, I think was pretty clear.

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Everyone I talked to said, you need at least 75% protected time to really be a strong physician

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scientist.

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That's the best place to start.

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Probably less than, you know, 20% clinical and you would lose your clinical footing.

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Like, you still need to see patients.

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But, you know, 75 to 80% is perfectly reasonable for a physician scientist with or without

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a lab.

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And then for startup and resources, I ended up just asking people who are going through

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the job process, maybe a year ahead of me, or even in my same year to, and it was very

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uncomfortable, but I would literally ask them if they would feel comfortable, you know,

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sharing their numbers with me.

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Like how much did you negotiate for?

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And from a basic science standpoint, like what's reasonable to negotiate for a lab?

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The number was way higher than I had ever expected.

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And then, you know, what do you negotiate when it comes to running a clinical trial

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for starting global studies?

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You know, what types of resources do you need?

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And with that, started putting together a budget of, you know, everything that I might

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potentially need to get my research program off the ground.

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And then, you know, ask different people.

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I asked you, I asked other people about, you know, what were kind of the key pieces of,

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for instance, personnel and support that you need and factor that into the budget as well,

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since, you know, salaries are usually the biggest money suck when you're talking about

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financing your own research.

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And so with all of that came, you know, came to a pretty comprehensive but impressive budget.

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And that is what I shared with the institutions that, you know, I negotiated with.

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And I think it was helpful for them to have a number to work with.

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And then also, it gave them a more concrete idea of, you know, what it was I was actually

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trying to accomplish in my first three years.

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And so I think that is, that's probably how I went about kind of getting ideas and kind

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of researching the process.

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And then I also took advantage of our, like, Office of Intramural Affairs.

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There was someone who you could actually talk to, to get advice on negotiation.

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So anytime I had an offer, or even just a phone conversation, I would, you know, run

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it by her and just get a sense like, did this go well?

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You know, what should I say here?

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Is this asking too much?

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Is this asking too little?

360
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It usually, the answer is you're asking too little.

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And she really helped me, you know, be bolder, because I think, especially as women in science,

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we don't tend to, we tend to ask for what we think is fair, not realizing that part

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of the negotiation is you need to ask for, you know, the maximum of what you need, and

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maybe a little more because you're never going to get that full ask.

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And so part of negotiation is being bold with your asks and knowing kind of the different

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components to ask for.

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So you know, just using all of these different resources, reading a couple of books about

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negotiation helped me expand the idea of like, what are the actual negotiables in these jobs?

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I love it.

370
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I love it.

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I see so much in that.

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So number one, you came prepared.

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You went and accessed resources, people, expertise, negotiation resources.

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You actually were so prepared.

375
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But see that as one preparation, which I think is so important to have any kind of successful

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negotiation.

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And then number two, I also see that you were looking when you didn't need to look.

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In a sense, you started early and you weren't desperate.

379
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You weren't like, I'm about to run out of money.

380
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I need a job, which really allows you to kind of take your time to think through the process

381
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and keep going back and forth in all the going back and forth that you needed.

382
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I also love that you made a budget and then you ask people what makes sense.

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Is this reasonable?

384
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And it's too little, it's too much.

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You didn't rely on yourself to be the source of all knowledge for moving forward.

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You really engaged all the resources that you had at your disposal.

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And then it sounds like you did it.

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You took bold steps and you up for things that I think made you feel uncomfortable.

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You said, this is what I need.

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And I think it's so powerful because you stand out to me as someone who's done things differently

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from many people who've come through clinical medicine where we're used to just getting

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what we get and we're used to just, you know, whatever you give me, thank you so much.

393
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But you really did something different.

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And you said, no, I want, I want to clarify what's needed.

395
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You asked, what do I need to be successful?

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You clarified that.

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And then you put together your own, this is what it looks, this is what I would need to

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be successful.

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And then you shared that with people.

400
00:29:29,040 --> 00:29:32,400
You knew from the beginning that you need the protected time.

401
00:29:32,400 --> 00:29:36,280
You knew you needed resources as far as setting up your own program.

402
00:29:36,280 --> 00:29:39,880
And you knew that because you went looking for information.

403
00:29:39,880 --> 00:29:43,840
And so I just want to pause and say to our listeners, if you are listening, I mean, Juliet's

404
00:29:43,840 --> 00:29:49,520
story is so awesome, but just it's so important to gather the information you need so that

405
00:29:49,520 --> 00:29:54,080
you can succeed in your negotiation so that you can set yourself up for success.

406
00:29:54,080 --> 00:29:59,880
You got to succeed in negotiation because it sets you up to succeed as a faculty person.

407
00:29:59,880 --> 00:30:03,080
And I think that's something that you really, really have done well, Juliet.

408
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And thank you for sharing that.

409
00:30:05,840 --> 00:30:06,840
Of course.

410
00:30:06,840 --> 00:30:07,840
Thank you.

411
00:30:07,840 --> 00:30:15,240
It's been a really great journey and definitely I've had a lot of moments along the way where

412
00:30:15,240 --> 00:30:17,360
I thought, can I really do this?

413
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Am I cut out for this?

414
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And am I really doing this in the right way?

415
00:30:22,160 --> 00:30:29,960
But I think, especially having peer mentors and mentors at different stages of their career

416
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to talk about these things with and get a sense of what are the tricks that I can use

417
00:30:36,880 --> 00:30:41,600
for getting to this next stage of my career has been really helpful.

418
00:30:41,600 --> 00:30:47,840
So I definitely encourage talking to as many people at any level of training as you can

419
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to kind of help you prepare for the academic journey.

420
00:30:51,720 --> 00:30:52,720
Absolutely.

421
00:30:52,720 --> 00:30:55,040
And you've really done that well.

422
00:30:55,040 --> 00:30:57,760
One of the things I want to point out that you did well is it's asking people at different

423
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institutions as well.

424
00:30:59,760 --> 00:31:04,600
And that's just so great to have such a rich perspective that's not just centered on one

425
00:31:04,600 --> 00:31:05,600
institution.

426
00:31:05,600 --> 00:31:06,600
This is the way we do things here.

427
00:31:06,600 --> 00:31:12,160
It's like, no, this is what makes sense across several institutions, which is really awesome.

428
00:31:12,160 --> 00:31:16,200
And that I think is a great segue into the next question, which is like, well, you know,

429
00:31:16,200 --> 00:31:17,800
you make this look so easy, Julia.

430
00:31:17,800 --> 00:31:22,720
It's like, wow, look at how much you've accomplished in such a little time.

431
00:31:22,720 --> 00:31:25,080
You as a resident were leading research projects.

432
00:31:25,080 --> 00:31:31,800
So was there any, I mean, what were the challenges, if any, that you faced along the way?

433
00:31:31,800 --> 00:31:32,800
Yeah.

434
00:31:32,800 --> 00:31:37,200
I know I definitely faced quite a few challenges.

435
00:31:37,200 --> 00:31:45,840
It was everything from not being able to get studies through the local IRBs, like the international

436
00:31:45,840 --> 00:31:52,040
IRBs, having things sit around for months, not knowing the right people or the right,

437
00:31:52,040 --> 00:31:56,640
I guess, phone calls to make to make things happen.

438
00:31:56,640 --> 00:32:01,040
Not having local buy-in and having to really generate that.

439
00:32:01,040 --> 00:32:06,120
And the Dominican Republic, I had to give talks and have frequent meetings with both

440
00:32:06,120 --> 00:32:12,560
the lab and the clinical team to explain why I thought this was an important clinical problem.

441
00:32:12,560 --> 00:32:20,160
And eventually after months, they got interested in the project and things went along swimmingly.

442
00:32:20,160 --> 00:32:25,120
But it was a lot of work trying to get local buy-in.

443
00:32:25,120 --> 00:32:31,880
And then there are all sorts of logistical, administrative barriers that you face.

444
00:32:31,880 --> 00:32:38,220
But I think one of the biggest things that I am still working on, and I think you probably

445
00:32:38,220 --> 00:32:44,240
work on for the rest of your life, is I guess the term is work-life integration.

446
00:32:44,240 --> 00:32:50,640
And along with that, I think integration of your clinical and your research role as well,

447
00:32:50,640 --> 00:32:53,560
I think is just very challenging.

448
00:32:53,560 --> 00:32:57,520
And I think it's an ever-moving target.

449
00:32:57,520 --> 00:33:03,040
And you probably never get it quite right, but you always move towards something that

450
00:33:03,040 --> 00:33:06,080
is tolerable and enjoyable, hopefully.

451
00:33:06,080 --> 00:33:13,520
But it's definitely something that's gotten more and more acute and important as I moved

452
00:33:13,520 --> 00:33:16,920
on to different phases of the academic career.

453
00:33:16,920 --> 00:33:22,380
As junior faculty now, really trying to make sure that I don't burn out because everyone

454
00:33:22,380 --> 00:33:26,000
keeps telling me, this is a marathon.

455
00:33:26,000 --> 00:33:29,840
Training might have felt like a sprint because you're always sprinting from one program to

456
00:33:29,840 --> 00:33:30,840
the next.

457
00:33:30,840 --> 00:33:37,560
I got to get this in so that I get accepted, so that I have a good match, et cetera.

458
00:33:37,560 --> 00:33:44,040
But once you get to being actual faculty, you don't have these little benchmarks to

459
00:33:44,040 --> 00:33:45,040
keep you going.

460
00:33:45,040 --> 00:33:49,720
You don't have something, a side post that tells you, oh, you've succeeded at this step.

461
00:33:49,720 --> 00:33:52,960
You can, here's the next step for you to move on to.

462
00:33:52,960 --> 00:33:59,760
It really is just this slow marathon that you have to keep up with, and you have to

463
00:33:59,760 --> 00:34:06,400
maintain your stamina and your interests, your passions, and your sanity.

464
00:34:06,400 --> 00:34:12,880
And so in order to do that, I think work-life integration is one of the most important things

465
00:34:12,880 --> 00:34:15,120
that I'm working on right now.

466
00:34:15,120 --> 00:34:20,040
And then wearing different hats as a clinician and a researcher, I'm constantly trying to

467
00:34:20,040 --> 00:34:27,360
decide should I work on my clinical inbox, answering patient calls, or should I be answering

468
00:34:27,360 --> 00:34:31,200
emails of my research study team, and I'm constantly flipping back and forth.

469
00:34:31,200 --> 00:34:37,400
And so that's something I haven't found a solution to, and it might just be a little

470
00:34:37,400 --> 00:34:42,480
bit of a flipping back and forth for the rest of your career.

471
00:34:42,480 --> 00:34:45,520
But I think it also keeps things interesting.

472
00:34:45,520 --> 00:34:52,240
I learned early on in my clinical training that when I was doing 100% research or 100%

473
00:34:52,240 --> 00:34:54,440
clinical, I just was not happy.

474
00:34:54,440 --> 00:34:57,600
I didn't feel fully fulfilled.

475
00:34:57,600 --> 00:35:03,720
And it's having the mix of both that really one inspires the other, and it really gives

476
00:35:03,720 --> 00:35:10,840
me that satisfaction of being a great provider, but also having a creative outlet and a way

477
00:35:10,840 --> 00:35:16,560
to make an impact that goes beyond just the patient sitting in front of me today.

478
00:35:16,560 --> 00:35:18,720
Wow.

479
00:35:18,720 --> 00:35:19,720
I love that.

480
00:35:19,720 --> 00:35:24,800
I think that you highlight something that's so important, is that the biggest obstacle

481
00:35:24,800 --> 00:35:32,160
or the biggest challenge is us, our capacity to integrate the things that are important.

482
00:35:32,160 --> 00:35:33,160
All of it is important.

483
00:35:33,160 --> 00:35:35,360
Your research is important.

484
00:35:35,360 --> 00:35:36,960
Your patients are important.

485
00:35:36,960 --> 00:35:38,680
The rest of your life is important.

486
00:35:38,680 --> 00:35:43,200
And how challenging it is to say, well, what is the priority in this moment?

487
00:35:43,200 --> 00:35:46,660
And what do I make sure I'm not neglecting in the moment as well?

488
00:35:46,660 --> 00:35:55,280
And so I think for our listeners, it's that as you get better, as you are able to clarify

489
00:35:55,280 --> 00:36:01,560
for yourself what is most important, it allows you to kind of recreate your environment or

490
00:36:01,560 --> 00:36:05,480
recreate your life, your experience to match those priorities.

491
00:36:05,480 --> 00:36:11,040
So that really, ultimately, along this journey, now that you stopped sprinting, and now that

492
00:36:11,040 --> 00:36:15,560
as a faculty member, you're now kind of looking at the long game.

493
00:36:15,560 --> 00:36:19,420
And to be honest, you've been doing that from the beginning, but now it's really a question

494
00:36:19,420 --> 00:36:20,920
of what do I want?

495
00:36:20,920 --> 00:36:21,920
How do I want to live?

496
00:36:21,920 --> 00:36:24,060
How do I want to lead this experience?

497
00:36:24,060 --> 00:36:25,440
And how do I make it all work?

498
00:36:25,440 --> 00:36:30,120
And it's so challenging because in a sense, it's about self mastery.

499
00:36:30,120 --> 00:36:31,440
And it's about other people.

500
00:36:31,440 --> 00:36:34,320
No longer are other people telling you what your goals should be.

501
00:36:34,320 --> 00:36:36,320
To some extent, they still do that.

502
00:36:36,320 --> 00:36:40,920
But really, you recognizing that they are not the ones with a yardstick of what success

503
00:36:40,920 --> 00:36:42,240
looks like.

504
00:36:42,240 --> 00:36:43,240
It's really you.

505
00:36:43,240 --> 00:36:49,080
Your measurement of success comes from your internal fulfillment and really feeling like

506
00:36:49,080 --> 00:36:51,640
you have things exactly where they need to be.

507
00:36:51,640 --> 00:36:56,240
And so I think it's a really important point in just how we're always kind of working on

508
00:36:56,240 --> 00:37:02,920
growing ourselves to become the kind of person who can lead the kind of careers that we want

509
00:37:02,920 --> 00:37:07,200
in that and the kind of fulfilling lives that we have in the process as well.

510
00:37:07,200 --> 00:37:08,200
Absolutely.

511
00:37:08,200 --> 00:37:10,120
You know, I completely agree.

512
00:37:10,120 --> 00:37:17,240
And I think one of the pitfalls of medical training is that we're kind of conditioned

513
00:37:17,240 --> 00:37:23,000
to externalize our self validation and our self worth.

514
00:37:23,000 --> 00:37:28,360
And it makes it really hard to listen to that inner voice say like, this is what I'm about.

515
00:37:28,360 --> 00:37:30,400
And this is why it's important to me.

516
00:37:30,400 --> 00:37:31,920
These are my values.

517
00:37:31,920 --> 00:37:38,200
We don't spend a lot of time thinking about it because we're just, you know, we were constantly

518
00:37:38,200 --> 00:37:43,480
being told this is what you need to do and this is who you need to be.

519
00:37:43,480 --> 00:37:48,060
And we're not really trained to think about, you know, those things for ourselves.

520
00:37:48,060 --> 00:37:54,760
And then it's a huge shock once you have that freedom to shape your own life and career.

521
00:37:54,760 --> 00:37:56,600
Absolutely.

522
00:37:56,600 --> 00:37:58,360
And it really, really is.

523
00:37:58,360 --> 00:38:03,360
It takes time and you've been practicing and continue to practice.

524
00:38:03,360 --> 00:38:04,680
It just, it's a lifelong.

525
00:38:04,680 --> 00:38:05,680
It's a lifelong journey.

526
00:38:05,680 --> 00:38:06,680
Absolutely.

527
00:38:06,680 --> 00:38:09,520
You know, Julia, it's been such a pleasure talking with you today.

528
00:38:09,520 --> 00:38:11,880
I mean, this conversation was so awesome.

529
00:38:11,880 --> 00:38:16,600
I want to say that I feel like our listeners are so fortunate to have this opportunity

530
00:38:16,600 --> 00:38:19,480
to listen to you, having you share your story.

531
00:38:19,480 --> 00:38:25,280
But I do feel like if there's one person out there saying, wow, Julia, can I do this?

532
00:38:25,280 --> 00:38:26,960
I've been in clinical training for 10 years.

533
00:38:26,960 --> 00:38:28,160
I haven't done what you've done.

534
00:38:28,160 --> 00:38:32,520
I didn't need a program as a medical student or as a resident.

535
00:38:32,520 --> 00:38:33,520
Is this for me?

536
00:38:33,520 --> 00:38:34,760
Can I be a clinician scientist?

537
00:38:34,760 --> 00:38:37,480
Can I also become a clinician researcher?

538
00:38:37,480 --> 00:38:39,960
What would you have to tell them?

539
00:38:39,960 --> 00:38:48,880
Well, I mean, I think probably the most important thing is to just get the experience and, you

540
00:38:48,880 --> 00:38:54,200
know, get out there and pursue some sort of research if you're thinking about it, you

541
00:38:54,200 --> 00:38:57,560
know, whether it's joining a lab or joining a clinical research project.

542
00:38:57,560 --> 00:39:04,040
I think until you start doing it, it's really hard to know, number one, is this something

543
00:39:04,040 --> 00:39:06,920
that you're interested in and passionate about?

544
00:39:06,920 --> 00:39:15,320
And number two, is it something that you, you know, have the patience and the, you know,

545
00:39:15,320 --> 00:39:16,960
perseverance to do?

546
00:39:16,960 --> 00:39:20,760
Because research is frustrating most of the time, right?

547
00:39:20,760 --> 00:39:24,640
Like it is not about big wins all the time.

548
00:39:24,640 --> 00:39:29,840
It's about taking advantage of or appreciating the little wins that you get along the way

549
00:39:29,840 --> 00:39:35,480
on a pretty challenging journey, but, you know, hopefully it's well worth it in the

550
00:39:35,480 --> 00:39:36,760
end.

551
00:39:36,760 --> 00:39:42,000
And so I think getting that experience and, you know, really deciding for yourself, is

552
00:39:42,000 --> 00:39:46,240
this something that I want to pursue would be the first step.

553
00:39:46,240 --> 00:39:51,480
And then after that, then you can ask yourself, you know, do I have the right setup, the right

554
00:39:51,480 --> 00:39:55,120
skills, the right training to do this?

555
00:39:55,120 --> 00:40:02,180
That might come in the form of talking to mentors or, you know, colleagues who are kind

556
00:40:02,180 --> 00:40:08,880
of doing research around your level, seeing what's actually needed to be successful at

557
00:40:08,880 --> 00:40:11,360
the next stages of your career.

558
00:40:11,360 --> 00:40:17,440
And realizing that with research, it's a long road where you're constantly acquiring

559
00:40:17,440 --> 00:40:21,400
new skills, and that's one of the big draws of research for me is that, you know, you're

560
00:40:21,400 --> 00:40:28,720
constantly learning and, you know, kind of evolving as a researcher.

561
00:40:28,720 --> 00:40:34,000
And so, you know, I don't think you should look at it and say like, oh, I'm never going

562
00:40:34,000 --> 00:40:37,640
to get there because I don't have X, Y, and Z skills.

563
00:40:37,640 --> 00:40:41,840
You look for the opportunity to pick up those skills.

564
00:40:41,840 --> 00:40:46,960
And maybe it takes a little bit longer, or maybe you happen to get all the skills in

565
00:40:46,960 --> 00:40:52,880
one project, but you just have to take it one step at a time and, you know, just keep

566
00:40:52,880 --> 00:40:57,160
building and knowing that it's kind of an incremental process to get to where you need

567
00:40:57,160 --> 00:40:58,160
to be.

568
00:40:58,160 --> 00:41:03,440
But I think really the first step is, you know, engaging and asking yourself, like,

569
00:41:03,440 --> 00:41:06,760
is this a path that I really want to pursue?

570
00:41:06,760 --> 00:41:09,600
And if so, go for it.

571
00:41:09,600 --> 00:41:10,600
I love it.

572
00:41:10,600 --> 00:41:12,000
I hear two things from what you said.

573
00:41:12,000 --> 00:41:15,880
Number one is stop waiting for someone to tell you, you can or can't.

574
00:41:15,880 --> 00:41:16,880
This is what you want to do.

575
00:41:16,880 --> 00:41:17,880
Go for it.

576
00:41:17,880 --> 00:41:18,880
Absolutely go for it.

577
00:41:18,880 --> 00:41:22,360
You've got to go for it as soon as you want, as soon as possible, because you want to know

578
00:41:22,360 --> 00:41:24,080
this is what you want to do.

579
00:41:24,080 --> 00:41:27,320
It's not glamorous.

580
00:41:27,320 --> 00:41:31,720
It's not, it's not like, you know, it's not the amazing thing that's always talked up

581
00:41:31,720 --> 00:41:32,720
to be.

582
00:41:32,720 --> 00:41:35,040
It's a lot of little battle every day.

583
00:41:35,040 --> 00:41:40,440
It's a lot of moving things forward incrementally, having conversations around whether it's

584
00:41:40,440 --> 00:41:42,320
work that needs to be done or not.

585
00:41:42,320 --> 00:41:44,960
So you want to know, is this the life you want?

586
00:41:44,960 --> 00:41:47,800
Is this something you're willing to fight for?

587
00:41:47,800 --> 00:41:50,400
Because it's a challenging journey, as you shared.

588
00:41:50,400 --> 00:41:51,560
It's not easy.

589
00:41:51,560 --> 00:41:55,120
And so if people are going to take this journey, they want to know that what they're doing

590
00:41:55,120 --> 00:42:00,680
is worth fighting for and that they're going to have the perseverance and the staying power

591
00:42:00,680 --> 00:42:03,760
to stay in the game because it's hard, it's challenging and there are other things to

592
00:42:03,760 --> 00:42:04,760
do.

593
00:42:04,760 --> 00:42:09,280
And so why stay and do something that you don't like and it's hard?

594
00:42:09,280 --> 00:42:12,040
So I really appreciate you sharing that perspective.

595
00:42:12,040 --> 00:42:14,520
And I just want to say thank you, Julia.

596
00:42:14,520 --> 00:42:16,920
It's just been such a great conversation.

597
00:42:16,920 --> 00:42:21,880
I learned a lot just listening to you and I know our listeners definitely have.

598
00:42:21,880 --> 00:42:25,960
So I just want to want to say thank you for coming on the show and thank you for just

599
00:42:25,960 --> 00:42:28,040
sharing your sage wisdom.

600
00:42:28,040 --> 00:42:29,660
Absolutely.

601
00:42:29,660 --> 00:42:30,660
This was such a pleasure.

602
00:42:30,660 --> 00:42:32,160
It was a great conversation.

603
00:42:32,160 --> 00:42:37,480
I really do hope that some of this advice and information can help your listeners.

604
00:42:37,480 --> 00:42:40,920
I think research is really rewarding.

605
00:42:40,920 --> 00:42:46,760
And if it's something like you said, if it's something that anyone has an inkling of an

606
00:42:46,760 --> 00:42:50,160
interest in, just go for it.

607
00:42:50,160 --> 00:42:56,440
It's waiting around for you to pick up and to run with it.

608
00:42:56,440 --> 00:42:57,440
Thank you, Julia.

609
00:42:57,440 --> 00:43:00,960
So everyone you heard, Julia, if you want to do it, you got to go for it.

610
00:43:00,960 --> 00:43:02,560
Don't wait for anyone to give you permission.

611
00:43:02,560 --> 00:43:04,920
You go figure out if this is what you want to do.

612
00:43:04,920 --> 00:43:07,840
So I want to say that Julia has shared with us so many awesome nuggets.

613
00:43:07,840 --> 00:43:12,560
If there is someone you know who needs to hear this, maybe a colleague or maybe even

614
00:43:12,560 --> 00:43:17,880
a mentee, if you're kind of a little further along, please share this episode with them

615
00:43:17,880 --> 00:43:23,720
and definitely make sure that Julia's wisdom gets shared with beyond more than just your

616
00:43:23,720 --> 00:43:29,200
immediate environment because this is so important for clinicians who are so capable, who are

617
00:43:29,200 --> 00:43:33,240
so able really to do whatever they want to do, whatever they set their hearts to do,

618
00:43:33,240 --> 00:43:36,160
to really figure out, hey, is this how I want to contribute in the world?

619
00:43:36,160 --> 00:43:38,920
And then to go for it and not to let anything stop them.

620
00:43:38,920 --> 00:43:43,240
And so I hope that you will definitely share this episode as widely as possible.

621
00:43:43,240 --> 00:43:44,880
And yeah, thank you for listening.

622
00:43:44,880 --> 00:43:51,560
We look forward again to the next time on the Clinician Researcher Podcast.

623
00:43:51,560 --> 00:43:57,760
Bye bye.

624
00:43:57,760 --> 00:44:03,120
Thanks for listening to this episode of the Clinician Researcher Podcast, where academic

625
00:44:03,120 --> 00:44:08,840
clinicians learn the skills to build their own research program, whether or not they

626
00:44:08,840 --> 00:44:09,920
have a mentor.

627
00:44:09,920 --> 00:44:16,040
If you found the information in this episode to be helpful, don't keep it all to yourself.

628
00:44:16,040 --> 00:44:17,760
Someone else needs to hear it.

629
00:44:17,760 --> 00:44:21,820
So take a minute right now and share it.

630
00:44:21,820 --> 00:44:27,280
As you share this episode, you become part of our mission to help launch a new generation

631
00:44:27,280 --> 00:44:33,520
of clinician researchers who make transformative discoveries that change the way we do health

632
00:44:33,520 --> 00:44:58,120
care in the most important person in history.

Julia Xu Profile Photo

Julia Xu

Assistant Professor of Medicine

Dr. Xu is an Assistant Professor of Medicine in the Division of Hematology/Oncology, Section of Benign Hematology, and the Vascular Medicine Institute at the University of Pittsburgh. She specializes in the care of adults with sickle cell disease (SCD). She received undergraduate degrees in biochemistry and Spanish and a Master of Science in chemistry from the University of Pennsylvania. She earned her MD from Columbia University, and with a strong interest in red cell disorders and health disparities, studied G6PD deficiency in an HIV clinic in the Dominican Republic as a Doris Duke Clinical Research Fellow. She pursued a combined internal medicine-global health residency at Duke University and obtained a Master of Science in Global Health. There, she studied the trajectory and predictors of renal function decline in the Duke adult SCD cohort. She also studied thalassemia screening in vulnerable migrant populations at Siriraj Hospital in Bangkok, Thailand, funded by the Cooley’s Anemia Foundation and the NIH/Fogarty International Center. She completed her hematology fellowship at the NIH, where she led early-phase clinical trials of a novel drug therapy for patients with SCD. Dr. Xu is dedicated to improving anemia and related chronic complications in individuals living with SCD globally. Her clinical and translational research program is focused on evaluating new drug therapies and biomarkers for improving anemia in SCD.